Will Ivermectin Kill Mange In Dogs

Mange in dogs is a contagious skin condition that causes severe discomfort, persistent itching, secondary skin infections, and hair loss. Ivermectin, a relatively recent option, has proven to be quite efficient in treating mange in dogs.

I have mange, how much ivermectin should I feed my dog?

Sarcoptic mange treatment dosage should not exceed 300 ug/kg, while dmod tic mange treatment dosage should range from 400 to 600 ug/kg. How much ivermectin paste should I feed my dog to cure sarcoptic mange? 300 ug/kg. Give 1 mg per pound as a single dosage for intestinal parasites.

How often should Ivermectin be used to treat mange?

The FDA has approved ivermectin products for the prevention of heartworm but not necessarily for other small animal anti-parasite purposes since the levels of ivermectin used for the prevention and treatment of heartworm disease are approximately 50 times lower than doses used for other parasites. (Acarexx for the treatment of ear mites and certain heartworm preventives have FDA approval, but other applications of ivermectin in small animals are “off label.”)

Ivermectin is administered daily or every other day for the treatment of demodectic mange, once a week or every few weeks for the majority of mites, and once a month for heartworm prevention.

It’s critical to administer a missed dose of heartworm prevention as soon as you remember it. Heartworm protection is no longer effective after a dose that is more than two weeks overdue.

In the other parasite treatments, if a dose is accidently missed, just resume with the subsequent dose. Never double up.

With the incredibly tiny doses used in commercially available heartworm preventives, side effects are not a concern.

If a patient has an unidentified P-glycoprotein gene mutation, complications may occur when greater doses are utilized, such as in mange or mite treatment. The P-glycoprotein has a role in preventing medicines from entering specific tissues in healthy persons and is crucial in preventing ivermectin from entering the patient’s nervous system. Ivermectin is safe for mammals even at large doses because of a healthy P-glycoprotein system. Unfortunately, mutations in the genes that produce P-glycoprotein are frequently found in breeds related to Collie dogs, including some other breeds. (This mutation was previously known as the “MDR1- mutation, but it has since been renamed the “ABCB1-1 mutation.”) This mutation may result in potentially harmful ivermectin sensitivity. The problem usually arises during the treatment of demodectic or sarcoptic mange since standard commercial heartworm preventives do not use high enough doses for it to become a concern.

For dogs of the following breeds, genetic testing is advised due to the prevalence of the P-glycoprotein gene mutation: Long-Haired Whippet, Australian Shepherd, Collie, Shetland Sheepdog, Old English Sheepdog, and potentially other herding breeds. You can order test kits directly from the Washington State University Veterinary School by clicking the link below, which uses a straightforward cheek swab:

Can mange be treated with ivermectin?

Ivermectin is most frequently prescribed to dogs and cats to prevent heartworm disease. Additionally, a number of internal and external parasites were treated with drugs that were “off label” or “extra-label.” Ivermectin, for instance, can be used to treat intestinal parasites including hookworms and roundworms in dogs as well as capillaries, mites, and scabies. Ivermectin can be used to treat cat scabies and ear mites in cats.

In veterinary medicine, many medications are frequently used for off-label uses. In these situations, pay close attention to your veterinarian’s instructions and warnings.

How is ivermectin given?

Other deworming drugs may be taken in addition to ivermectin. Ivermectin is offered as tablets, chewable tablets, a topical liquid (for treating ear mites), and an injection that will be given to your pet by your veterinarian.

You can administer it with or without food. Give the medication with food or a little treat to see if that helps if your pet vomits or acts sick after receiving it on an empty stomach. In case the vomiting persists, call your veterinarian.

The procedure for applying topical ivermectin to your pet’s ears will be explained by your veterinarian.

The effects of this drug should be felt within one to two hours, but they might not be immediately apparent. As a result, laboratory tests may be necessary to assess this medication’s efficacy.

What if I miss giving my pet the medication (or my shipment is late)?

As soon as you remember, administer the missing dose; after that, wait the period of time between doses that your veterinarian has advised before administering the subsequent dose. Don’t administer additional dosages or two doses at once to your dog.

If you are taking ivermectin to prevent heartworms and it has been more than 8 weeks since your last dose, speak with your veterinarian for advice.

Are there any potential side effects?

Ivermectin is normally well tolerated but when used in large doses, such as for mite infestations, it can have substantial neurological adverse effects.

Certain breeds, like collies, are only moderately sensitive to ivermectin dosages and may have negative effects at lesser levels.

Some dogs may get a reaction resembling shock from ivermectin. Contact your veterinarian if this occurs.

Contact your veterinarian if you have any side effects, including as nausea, vomiting, diarrhea, dilated pupils, unsteadiness when walking, or a confused temperament.

The effects of this quick-acting medicine should wear off after 24 hours, though they may last longer in animals with liver or renal illness.

Are there any risk factors for this medication?

Ivermectin shouldn’t be administered to puppies under 6 weeks of age or to animals lacking a recent negative heartworm test.

Ivermectin sensitivity varies among dog breeds; examples include collies, sheepdogs, and collie- or sheepdog-cross breeds. This is frequently caused by a particular genetic mutation (MDR1) that reduces their tolerance for large doses of ivermectin. These dog breeds can safely receive heartworm preventive doses.

Are there any drug interactions I should be aware of?

There are some drugs that intensify ivermectin’s effects in a pet’s brain (e.g., ketoconazole, itraconazole, cyclosporine, erythromycin, amlodipine besylate, and nifedipine). Spinosad, a popular flea preventive medication, should not be supplied when high dosages of ivermectin are used to treat mite infestations. Combining spinosad with the minimal doses of ivermectin seen in heartworm preventives is safe.

Tell your vet about any medications your pet is receiving, including vitamins, supplements, and herbal treatments.

Is there any monitoring that needs to be done with this medication?

Before administering the medication, screening may be carried out on breeds of dogs who may be sensitive to ivermectin. A pet’s genetic mutation that causes negative reactions to ivermectin can be detected by DNA testing.

How do I store ivermectin?

Ivermectin-based products should be kept at room temperature, away from heat sources, in a dry, cold environment. The effectiveness of the medication may be lowered by heat or moisture exposure.

What should I do in case of emergency?

Call your veterinarian’s office right away if you think your pet may have taken too much medication or is having an unfavorable reaction to it. Follow their instructions for contacting an emergency facility if they are not readily available.

How quickly can mange be removed from a dog?

There are a few potential at-home treatments for mange. Mange may be treated at home with bathing, spot cleaning, or food additives, but it is preferable to contact your veterinarian if any of the home therapies are not effective.

The mange mites may be removed with the aid of an apple cider vinegar soak. Borax and warm water are combined with 1/2 cup of apple cider vinegar. Before applying the mixture to your dog’s skin and coat, make sure the borax is completely dissolved. Additionally, watch out that your dog doesn’t lick the liquid because Borax ingestion might be dangerous. If required, wear an Elizabethan collar. Bypass the mouth and eyes when applying the mixture to your dog’s complete body and coat. Then, without towel drying, let the solution air dry.

Without bathing the entire dog, you can apply the same solution in a spray bottle to smaller patches of skin and fur on your dog. Small pets or small impacted areas are ideal for this.

You can also use apple cider vinegar in your dog’s food or water. Mange may be treated by adding a teaspoon for dogs under 30 pounds or a tablespoon for dogs over 30 pounds to their food bowl. Due to its antiseptic and antibacterial characteristics, apple cider vinegar will aid in your dog’s recovery and help to maintain the right pH levels for skin healing.

Honey has amazing medicinal qualities and can treat a wide range of conditions in both humans and animals. The sensitive, delicate skin will heal because to its antibacterial and antioxidant characteristics, which will also aid develop immunity. Honey can also rid the skin of bacteria and mange-related filth and grime. For treatment, directly apply honey to the skin lesions on your dog. Although untidy, this procedure may be beneficial.

Olive oil can help soothe the sensitive skin and possibly get rid of the mange mites by being applied directly to the affected regions.

Sponge Mange is commonly treated by giving your dog a bath in a solution of Borax and hydrogen peroxide. Combining Borax and hydrogen peroxide may aid in the removal of mange mites and the healing of skin ulcers.

Regular use of these remedies may help your dog get rid of mange, and weekly application may prevent recurrence. The best course of action would be to consult a veterinarian if the issue is not getting better because there are extremely effective medications available to treat it.

How quickly does ivermectin start killing Demodex mites?

Following ivermectin therapy, the recovery period lasts for the majority of patients between 2 and 8 weeks (as measured by clinical improvement and skin scrapings negative for mites). Immunocompromised patients may experience particularly refractory conditions that take weeks or months to resolve.


The electronic databases CAB Direct, PubMed, Scopus, Web of Science, EMBASE, and Discovery were all thoroughly searched. Extracted information on study design, nation, year, species, study size, mange severity, treatment strategy, and results was put into a table from eligible studies. After data extraction, a decision tree was utilized to find studies that were appropriate for additional analysis based on the efficacy of their treatment technique, whether they involved captive or non-captive species, and the caliber of their post-treatment monitoring period.


Our initial inclusion criteria for data gathering were met by 28 studies. After using the decision tree, 15 of these studies were chosen for additional examination. This included 1 study including both captive and free-living animals, 5 studies on wildlife in the wild, and 9 studies on species kept in captivity. The most popular and effective treatment was determined to be ivermectin provided repeatedly via subcutaneous injection at a dose between 200400 g/kg, while long-term statistics on post-release survival and re-infection rates were difficult to come across.


This review is the first to show that different therapeutic approaches exist for treating sarcoptic mange in wildlife, to our knowledge. Many modern treatment approaches, such as the one-time application of isoxazoline drugs, have not yet been properly described in animals. Additionally, there is a clear need for more randomised controlled studies and better post-treatment monitoring techniques. The expansion of knowledge in this area is anticipated to help veterinarians, wildlife specialists, and decision-makers develop and put into practice efficient management and treatment plans for the conservation of wildlife that has sarcoptic mange.

How can you tell when mange is getting better?

Hair loss, blisters and scabbing, irritated skin, and severe itching are typical mange symptoms. Mange treatment can last a month or longer, so as time goes on, you should notice the symptoms getting fewer and less noticeable. Your dog may still have noticeable spots when the therapy is over, but you should start to notice some hair returning. The itching will stop once the mites and any subsequent skin illnesses disappear.

How do veterinarians treat mange?

Depending on whether a dog or cat has a localized or generalized mange infestation (demodex), the treatment differs.

Even if they are not treated, 90% of young, healthy pets with localized mange infections recover within two months. A topical antibacterial agent, such as Be Super Clean, may be beneficial for these animals. Although the shampoo doesn’t get rid of demodex mites, it does assist in preventing bacterial skin infections brought on by excessive scratching.

Less than a year old animals with generalized mange infection have a 30-50% chance of recovering from the infection, despite the fact that it is severe. These animals do not always require medical attention since their immune systems work to eradicate the infection. A prescription medicine, such as sulfurated lime or amitraz (Mitaban Dip for dogs), is used for animals that do not naturally clear an infection.

Sulfur and lime are combined to create sulfurated lime, which is used to treat pets for bacterial, parasitic, and fungal illnesses such ringworm, sarcoptes scabiei mites, and mange demodex mites. Additionally, ringworm and parasitic irritation are reduced by sulfurized lime.

Every 5-7 days, sulfur and lime solutions are applied as a rinse or dip to treat mange (demodex) infections. Until skin scrapings have been free of mites for at least a month, the treatment is repeated multiple times over a period of weeks. When diluted in one gallon of water with four ounces of sulfuric acid, sulfuric acid can be safely applied to dogs, cats, puppies, and kittens. Eight ounces of sulfurated lime can be used per gallon of water if this concentration is ineffective in curing the mite infection.

Unfortunately, sulfur has an unpleasant smell, thus the dip should be applied in an area with good ventilation. As the dip dries, the fragrance gradually fades. Your pet is not cleaned or allowed to get wet in between sessions; the dip is simply kept on the skin without being towel dried. Jewelry, porous surfaces like cement, and the white or light-colored coats of dogs are all stained by sulfurated lime dips. Over time, the discolored coat changes back to its original hue. Benzoyl peroxide shampooing your pet prior to dipping improves mite exposure to the dip by opening skin follicles.

Amitraz is a substance (triazapentadiene) that eliminates spiders and insects from plants, animals, and homes. Mitaban Dip is one of the amitraz formulations (for dogs). Amitraz is used in veterinary medicine to eradicate ticks, mites, and lice. The FDA has given the drug amitraz approval for weekly use in dogs that are at least four months old. Utilizing amitraz in cats is “off-label.” Veterinarians may recommend more frequent dips or dips with higher concentrations than usual for animals with illnesses that do not respond to weekly dips. Both of these procedures are regarded as “off label” uses of amitraz. Up to 20% of adult pets with widespread demodex infection do not improve despite these changes.

Because amitraz is somewhat poisonous, amitraz dips should only be performed under a veterinarian’s supervision. The tips below will help make the dip efficient and secure for both you and your pet:

  • Use with caution on animals with draining, deep bacterial infections. First, treat skin infections.
  • If your pet’s hair isn’t already short, clip it.
  • Before dipping, give your pet a benzoyl peroxide bath. This washing enhances mite exposure to the dip and opens skin follicles.
  • To prevent getting dipped, put cotton balls in the ears of your pet and protective eye ointment in the eyes. Avoid getting water in your pet’s mouth or lips; instead, gently sponge the area around its head.
  • Dip the rest of your pet completely.
  • Do not wipe off the dip with a towel or rinse it off. In between treatments, avoid letting your pet swim or get wet.
  • Repeat the dip every one to two weeks until there are no live or dead mites in skin scrapings for at least a month. Skin scrapings are collected from locations with and without hair.
  • Wear protective clothing and take off your jewelry before applying the dip to your pet because amitraz will discolor it.
  • Work somewhere with good ventilation, but keep your pet from getting too cold.

Some vets advise soaking your dog’s paws in amitraz mixed with mineral oil if they have demodex paw infections. Although this is “off label” use, it can be very successful.

Amitraz is a potent drug that can have negative effects on canines. After being dipped, the majority of dogs get drowsy. Toy breeds, elderly, frail, and weak animals, cats, and rabbits are more prone to be poisoned by amitraz. High blood sugar, vomiting, diarrhea, ataxia, and a slowed heartbeat are all toxic symptoms.

Diabetes patients and those using MAO inhibitors like parnate and selegiline shouldn’t use amitraz. On dogs on Anipryl or Selegiline for Cushing’s disease or canine cognitive dysfunction syndrome, Amitraz should not be administered (senility). For these animals, sulfurated lime is a safer treatment.

If sulfurated lime or Mitaban Dip do not successfully treat the mange (demodex) infection, or to hasten the healing process, the following steps are taken:

  • relieve pressure points like pregnancy
  • Boost your immunity
  • Underlying underlying illnesses or infections
  • Give your dog Heartgard Plus Chewables (ivermectin) or any other medication that your vet has given to you.

Sulfuric acid or amitraz are the recommended treatments for mange (demodex), but if those do not work, veterinarians may advise administering high doses of prescription drugs like Heartgard Plus Chewables (ivermectin).

For 2-3 months, Heartgard, which is administered at a dose of 6 micrograms/kg/month to prevent heartworm infections, is given at a dose of 600 micrograms/kg/day, which is 100 times the heartworm dose. Treatment is continued for at least a month after dogs’ skin scrapings show no live or dead mites. The medicine Interceptor (0.5-0.9mg/kg/month) is frequently used to stop heartworm infections. Veterinarians recommend using greater doses (0.5 to 2.0 mg/kg) every day for several weeks to cure demodex mites. Until skin scrapings have been free of live or dead mites for at least a month, the interceptor is kept in place.

Two crucial safety measures are implemented due to the high doses of Heartgard or Interceptor that are required to cure pets of demodex. Before receiving therapy, dogs are tested first to rule out the presence of heartworms and then, whether they are purebred or mixed-breed herding dogs, to rule out the presence of the MDR1 gene:

  • Australia Terrier
  • Cross-country dog
  • Collie
  • German Shepherd
  • English Shepherd
  • McNab
  • Sheepdog in Old English
  • Whippet with long hair
  • Windhound Silken

Heartworm and demodex infections in dogs can still be properly treated. These dogs are first given mild doses of heartworm medication to treat their heartworm infections, and then they are given large doses of ivermectin (Heartgard) or milbemycin to treat their demodex infestations.

Some veterinarians advise using the Preventic Amitraz Tick Collar for Dogs “off-label” to help treat mange demodex mite infections because it includes amitraz. The collar works best when worn in between applications of Mitaban Dip or sulfurated lime.

Because amitraz might cause allergic reactions in cats, your veterinarian may advise combining it (1:3) with mineral oil or propylene glycol and treating only the problematic regions.

Give your pet no oral steroids, such as Prednisone and Prednisolone, unless specifically prescribed by a veterinarian to treat mange. Additionally, you shouldn’t treat pets with mange infestations with topical drugs.

Supplements containing fatty acids and immune-boosting antioxidants are beneficial for pets with mange.